This page provides answers to your questions before using Isotretinoin (commonly known as Roaccutane).
What is Isotretinoin?
Isotretinoin—marketed under brand names such as Roaccutane, Accutane, or Zoretanin—is a vitamin A derivative. It is primarily prescribed for the treatment of severe acne that has not responded to other therapies. It is available only by medical prescription.
What are the indications for Isotretinoin?
Isotretinoin is used in the treatment of dermatological conditions such as:
- •Severe acne
- •Rosacea
- •Pyoderma gangrenosum
- •Folliculitis decalvans
Is Isotretinoin effective, and how does it work?
Yes, it is effective. Its mechanism of action includes:
- •Reducing the size of sebaceous glands
- •Decreasing follicular obstruction
- •Lowering sebum production
- •Preventing bacterial overgrowth and inflammation
What should you consider before obtaining Isotretinoin?
Isotretinoin must not be used without a medical prescription. A healthcare professional will ensure that it does not interact with other medications and is appropriate for your health condition.
Frequently Asked Questions
What are the side effects of Isotretinoin?
Isotretinoin may cause several side effects, including:
- •Acne flare-up during the initial stage of therapy
- •Dry skin, chapped or bleeding lips
- •Dry hair and hair loss
- •Brittle and fragile nails
- •Dry eyes, keratitis, or conjunctivitis
- •Nasal dryness and epistaxis (nosebleeds)
- •Pruritus, eczema, and skin infections such as impetigo and acute paronychia
- •Photosensitivity reactions
- •Pyogenic granuloma
- •Headache, fatigue, and lethargy
- •Musculoskeletal pain (muscle and joint pain)
- •Hypertriglyceridemia
- •Menstrual irregularities
- •Neuropsychiatric effects such as depression
What are the guidelines for using Isotretinoin?
- •Dosage adherence:
The dosage depends on body weight, disease severity, therapeutic response, concomitant medications, and side effects. Always consult a dermatologist before use to prevent complications.
- •Administration instructions:
Swallow the capsule with a full glass of water, preferably after a meal.
- •Storage recommendations:
Store at 20–25 C, away from direct sunlight. Check the expiration date on the package before use. Do not use it after the expiry date.
What are the warnings and precautions for Isotretinoin use?
- •Contraindicated during pregnancy due to the risk of miscarriage or severe congenital malformations.
- •Consultation is required during breastfeeding.
- •Should be avoided in patients with severe hepatic or renal impairment, hyperlipidemia, diabetes mellitus, or a history of depression. If prescribed, dosage adjustments and close monitoring are required.
- •Blood donation is prohibited for at least one month following the last dose.
Frequently Asked Questions
What should I do if I miss a dose?
Take the missed dose as soon as you remember, provided that the next scheduled dose is not imminent. Never take two doses at the same time.
How long should Isotretinoin therapy last?
Treatment duration varies by case, but it typically ranges between 4 and 6 months.
What are the health education guidelines while on Isotretinoin?
- •Drink sufficient amounts of water.
- •Use fragrance-free, non-exfoliating moisturizers regularly to prevent dryness of the skin, lips, and eyes.
- •Avoid fast food to reduce the risk of elevated harmful lipids that may affect liver function tests.
- •Always apply sunscreen when outdoors.
- •Do not take any medications without prior medical consultation.
